AlveoSafe: Tools and an algorithm for real-time evaluation of lung injury processes during mechanical ventilation
Tulane researchers have discovered the precise mechanism behind ventilator-induced lung injury (VILI), identifying alveolar recruitment/derecruitment as the primary cause. This breakthrough enables development of targeted monitoring systems and ventilation strategies that could dramatically reduce the 30-40% mortality rate among patients with acute respiratory distress syndrome (ARDS).
The Problem
Mechanical ventilators are life-saving but can inadvertently injure patients through mechanisms that have remained unclear for decades. Despite improved ventilation strategies, clinicians cannot identify which specific aspect of mechanical ventilation causes the most harm to lung tissue. This uncertainty has prevented development of effective protective strategies, leaving ARDS mortality rates persistently high at 30-40%.
The Solution
AlveoSafe identifies that alveolar recruitment/derecruitment (RD) causes VILI by creating localized "tiny explosions" at lung surfaces with power intensity of ~100 W/m². By analyzing energy transport and dissipation during mechanical ventilation, the method pinpoints the critical 2% of ventilation energy that injures patients. The discovery apparatus and process can be adapted to clinical settings with identified intervention thresholds.
The Opportunity
This technology addresses the $5+ billion global ventilator market, with ARDS affecting roughly 10% of ICU patients. Applications include real-time RD monitoring systems, AI-driven closed-loop ventilation control that automatically minimizes harmful cycles, and integrated treatment optimization platforms for ARDS management. By targeting the specific injury mechanism, the technology enables development of precision ventilation strategies that could significantly improve patient outcomes and reduce healthcare costs.
